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dc.contributor.authorCid, Sandra-
dc.contributor.authorEiro, Noemi-
dc.contributor.authorFernández, Berta-
dc.contributor.authorSánchez, Rosario-
dc.contributor.authorAndicoechea, Alejandro-
dc.contributor.authorFernández-Muñiz, Pablo Igancio-
dc.contributor.authorGonzález, Luis O.-
dc.contributor.authorVizoso, Francisco J.-
dc.date.accessioned2018-12-05T07:34:28Z-
dc.date.available2018-12-05T07:34:28Z-
dc.date.issued2018-02-
dc.identifier.citationCid, Sandra; Eiro, Noemí; Fernández, Berta; Sánchez, Rosario; Andicoechea, Alejandro; Fernández-Muñiz, Pablo Ignacio; González, Luis O; Vizoso, Francisco J. Prognostic Influence of Tumor Stroma on Breast Cancer Subtypes. Clin Breast Cancer. 2018 Feb;18(1):e123-e133eng
dc.identifier.issn1526-8209-
dc.identifier.urihttps://ria.asturias.es/RIA/handle/123456789/10906-
dc.description.abstractAims: The objective of the present work was to evaluate the impact of the phenotype of both intratumoral mononuclear inflammatory cells (MICs) and cancer-associated fibroblast (CAFs), assessed as to their expression of MMPs and TIMPs on prognosis in different breast cancer subtypes. Materials and Methods: 247 tumors of patients with primary ductal invasive breast cancer were categorized into one of four major subtypes, using the three standard immunohistochemical markers (ER, PR and HER/Neu 2 receptor status). An immunohistochemical study was performed using tissue arrays and specific antibodies against matrix metalloproteinase (MMP)-9, -11 and -14, and tissue inhibitors of metalloproteinase (TIMP)-1 and –2. Results: MMP-11 expression by MICs was significantly and strongly associated with prognosis in all breast cancer subtypes. There were other significant associations with poor prognosis in Luminal A tumors: expressions of MMP-9, -11, and TIMP-2 by CAFs, in Luminal B tumors: MMP-14 expression by MICs and TIMP-2 expression by MICs, in HER-2-positive tumors: expression of MMP-9 by MICs and in triple-negative breast cancers (TNBC): expression of TIMP-1 by MICs. Conclusion: Characterization of both tumor stromal CAFs and MICs, with regard to the expression of MMPs and TIMPs, improve the prognostic evaluation of all breast cancer subtypes.eng
dc.language.isoengeng
dc.relation.ispartofClinical Breast Cancereng
dc.relation.haspart18eng
dc.relation.hasversion1eng
dc.relation.isreferencedbyNo, esta versión no ha sido citadaeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
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dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
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dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/deed.eseng
dc.sourcee123;e133-
dc.subjectCancer-associated fibroblastseng
dc.subjectIntratumoral inflammatory cellseng
dc.subjectMMPseng
dc.subjectMolecular subtypeeng
dc.subjectTIMPseng
dc.subject.classificationPublicadoeng
dc.titlePrognostic Influence of Tumor Stroma on Breast Cancer Subtypeseng
dc.typearticleeng
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