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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/12525


Título: Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes
Autores: Rodríguez López, Ramón M
Suárez Álvarez, Beatriz
Lavín, José L
Ascensión, Alex M
González, Monika Monika
Lozano, Juan J
Raneros Baragaño, Aroa
Díaz Bulnes, Paula
Vidal Castineira, Jose R
Huidobro Fernández, Covadonga
Martín Martín, Cristina
Sanz, Ana B
Ruiz Ortega, Marta
Puig Kroger, Amaya
Corbi, Angel L
Arauzo Bravo, Marcos J
Aransay, Ana M
Lopez Larrea, Carlos
Palabras Claves: Macrophage Polarization
Gene-Expression
DNA Methylation
Read Alignment
Cancer
Plasticity
Chromatin
Cytokine
Fecha Edición: 22-Oct-2019
Editor: Cell Press
Cita Bibliográfica: Rodriguez RM, Suarez-Alvarez B, Lavín JL, Ascensión AM, Gonzalez M, Lozano JJ, Raneros AB, Bulnes PD, Vidal-Castiñeira JR, Huidobro C, Martin-Martin C, Sanz AB, Ruiz-Ortega M, Puig-Kröger A, Corbí AL, Araúzo-Bravo MJ, Aransay AM, Lopez-Larrea C. Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes. Cell Rep. 2019 Oct 22;29(4):860-872.e5. doi: 10.1016/j.celrep.2019.09.035. PMID: 31644909
Resumen: : In recent years, the macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage CSF (GM-CSF) cytokines have been identified as opposing regulators of the inflammatory program. However, the two cytokines are simultaneously present in the inflammatory milieu, and it is not clear how cells integrate these signals. In order to understand the regulatory networks associated with the GM/M-CSF signaling axis, we analyzed DNA methylation in human monocytes. Our results indicate that GM-CSF induces activation of the inflammatory program and extensive DNA methylation changes, while M-CSF-polarized cells are in a less differentiated state. This inflammatory program is mediated via JAK2 associated with the GM-CSF receptor and the downstream extracellular signal-regulated (ERK) signaling. However, PI3K signaling is associated with a negative regulatory loop of the inflammatory program and M-CSF autocrine signaling in GM-CSF-polarized monocytes. Our findings describe the regulatory networks associated with the GM/M-CSF signaling axis and how they contribute to the establishment of the inflammatory program associated with monocyte activation.
URI: https://ria.asturias.es/RIA/handle/123456789/12525
ISSN: 2211-1247
Aparece en las Colecciones:Sanidad

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