Datos del Documento

Por favor, use este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/13645
Título : On the quest for In Vitro Platelet Production by Re-Tailoring the Concepts of Megakaryocyte Differentiation
Autor : Martínez Botía, Patricia
Acebes-Huerta, Andrea
Seghatchian, Jerard
Gutiérrez, Laura
Palabras clave : platelet transfusion; megakaryocyte differentiation; in vitro platelet production; cell source; cell reprogramming
Fecha de publicación : dic-2020
Editorial : Medicina
Resumen : The demand of platelet transfusions is steadily growing worldwide, inter-donor variation, donor dependency, or storability/viability being the main contributing factors to the current global, donor-dependent platelet concentrate shortage concern. In vitro platelet production has been proposed as a plausible alternative to cover, at least partially, the increasing demand. However, in practice, such a logical production strategy does not lack complexity, and hence, efforts are focused internationally on developing large scale industrial methods and technologies to provide efficient, viable, and functional platelet production. This would allow obtaining not only sufficient numbers of platelets but also functional ones fit for all clinical purposes and civil scenarios. In this review, we cover the evolution around the in vitro culture and differentiation of megakaryocytes into platelets, the progress made thus far to bring the culture concept from basic research towards good manufacturing practices certified production, and subsequent clinical trial studies. However, little is known about how these in vitro products should be stored or whether any safety measure should be implemented (e.g., pathogen reduction technology), as well as their quality assessment (how to isolate platelets from the rest of the culture cells, debris, microvesicles, or what their molecular and functional profile is). Importantly, we highlight how the scientific community has overcome the old dogmas and how the new perspectives influence the future of platelet-based therapy for transfusion purposes
URI : http://ria.asturias.es/RIA/handle/123456789/13645
Aparece en las colecciones: Sanidad

Archivos en este documento:
Fichero Tamaño Formato  
Medicina_review_dic2020.pdf1.42 MBAdobe PDFVer/Abrir
Mostrar el registro Completo

Ver estadísticas del documento

Este documento está sujeto a una licencia Creative Commons: Licencia Creative Commons Creative Commons