Ir a la página de inicio del Gobierno del Principado de Asturias

Datos del Documento

Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/13786


Título: Role of the RANK/RANKL/OPG and Wnt/β‑Catenin Systems in CKD Bone and Cardiovascular Disorders
Autores: Carrillo‑López, Natalia
Martínez‑Arias, Laura
Fernández‑Villabrille, Sara
Ruiz‑Torres, María Piedad
Dusso, a
Cannata‑Andía, Jorge B.
Naves-Díaz, Manuel
Panizo, Sara
Palabras Claves: RANK/RANKL/OPG system
LGR4
Wnt/β-catenin pathway
PTH
Klotho
Phosphorus
Fecha Edición: Feb-2021
Editor: Calcified Tissue International
Resumen: In the course of chronic kidney disease (CKD), alterations in the bone-vascular axis augment the risk of bone loss, fractures, vascular and soft tissue calcification, left ventricular hypertrophy, renal and myocardial fibrosis, which markedly increase morbidity and mortality rates. A major challenge to improve skeletal and cardiovascular outcomes in CKD patients requires a better understanding of the increasing complex interactions among the main modulators of the bone-vascular axis. Serum parathyroid hormone (PTH), phosphorus (P), calcium (Ca), fibroblast growth factor 23 (FGF23), calcidiol, calcitriol and Klotho are involved in this axis interact with RANK/RANKL/OPG system and the Wnt/β-catenin pathway. The RANK/RANKL/OPG system controls bone remodeling by inducing osteoblast synthesis of RANKL and downregulating OPG production and it is also implicated in vascular calcification. The complexity of this system has recently increased due the discovery of LGR4, a novel RANKL receptor involved in bone formation, but possibly also in vascular calcification. The Wnt/β-catenin pathway plays a key role in bone formation: when this pathway is activated, bone is formed, but when it is inhibited, bone formation is stopped. In the progression of CKD, a downregulation of the Wnt/β-catenin pathway has been described which occurs mainly through the not coincident elevations of sclerostin, Dickkopf1 (Dkk1) and the secreted Frizzled Related Proteins (sFRPs). This review analyzes the interactions of PTH, P, Ca, FGF23, calcidiol, calcitriol and Klotho with the RANKL/RANKL/OPG system and the Wnt/β-catenin, pathway and their implications in bone and cardiovascular disorders in CKD.
URI: https://ria.asturias.es/RIA/handle/123456789/13786
Aparece en las Colecciones:Sanidad

Archivos en este documento:



Archivo TamañoFormato
Role of the RANKRANKLOPG.pdf430,12 kBAdobe PDFVer/Abrir



logo

Todos los documentos en RIA están protegidos por derechos de autor.


Valid XHTML 1.0! DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - Contacto