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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/14366


Título: Effects of calcitriol and paricalcitol on renal fibrosis in CKD.
Autores: Martinez Arias, Laura
Panizo García, Sara
Alonso Montes, Cristina
Martín Virgala, Julia
Martín Carro, Beatriz
Fernández Villabrille, Sara
García Gil-Albert, Carmen
Palomo Antequera, Carmen
Fernández Martín, José Luis
Ruiz Torres, María Piedad
S. Dusso, Adriana
Carrillo Lopez, Natalia
Cannata Andía, Jorge B.
Naves Diaz, Manuel
Palabras Claves: ckd
renal fibrosis
inflamatory infiltration
epithelial/mesenchymal-transition
VIDRAs
Fecha Edición: 26-Abr-2021
Cita Bibliográfica: 10.1093/ndt/gfaa373
Resumen: BACKGROUND: In chronic kidney Disease (CKD) the activation of the renin-angiotensin-aldosterone system and renal inflammation stimulate renal fibrosis and the progression to end-stage renal disease. The low levels of vitamin D receptor (VDR) and its activators (VDRAs) contribute to worsen secondary hyperparathyroidism and renal fibrosis. METHODS: The 7/8 nephrectomy model of experimental chronic renal failure (CRF) was used to examine the antifibrotic effects of treatment with two VDRAs (paricalcitol and calcitriol at equivalent doses (3/1 dose ratio) during 4 weeks. RESULTS: CRF increased the activation of the renin-angiotensin-aldosterone system, renal inflammation and interstitial fibrosis. Paricalcitol treatment reduced renal collagen I and renal interstitial fibrosis by decreasing the activation of the renin-angiotensin-aldosterone system through renal changes in renin, ATR1 and ATR2 mRNAs levels and renal inflammation by decreasing renal inflammatory leukocytes (CD45), ADAM17 mRNA, TGF-β mRNA and protein and maintaining E-cadherin mRNA levels. Calcitriol showed similar trends without significant changes in most of these biomarkers. CONCLUSIONS: Paricalcitol effectively attenuated the renal interstitial fibrosis induced by CRF through a combination of inhibitory actions on the renin-angiotensin-aldosterone system, inflammation and epithelial/mesenchymal transition.
URI: https://ria.asturias.es/RIA/handle/123456789/14366
Aparece en las Colecciones:Sanidad

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