Optimization of drug specific memory T-Lymphocytes detection in a case of severe dress syndrome

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe multiorgan hypersensitivity reaction caused by some drugs and mediated by T-lymphocytes. When a DRESS is diagnosed, it is necessary to confirm that the suspicious drug is the cause of the reaction in order either to avoid a new exposition to this drug or to prevent from an unnecessary avoidance of a drug. However, in vitro techniques currently used have quite limitations. The aim of this work is to study the case of a severe DRESS syndrome probably caused by minocycline that triggered in a fulminant hepatitis and the requirement of liver transplantation in a fifteen years old patient .