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dc.contributor.authorCoto, Eliecer-
dc.contributor.authorMena, Lorena-
dc.contributor.authorRibacoba, René-
dc.contributor.authorMorís, Germán-
dc.contributor.authorMenéndez, Manuel-
dc.contributor.authorÁlvarez, Victoria-
dc.date.accessioned2013-04-16T08:44:45Z-
dc.date.available2013-04-16T08:44:45Z-
dc.date.issued2013-
dc.identifier.urihttps://ria.asturias.es/RIA/handle/123456789/2743-
dc.description.abstractPlasma microRNAs (miRNAs) are promising biomarkers for several diseases. Our aim was to define the miRNA profile in plasma from Parkinson´s disease (PD) patients and healthy controls. We performed TaqMan low density arrays (TLDAs) in pools of patients and controls. Seven miRNAs differently expressed between the two groups were individually assayed in a total of 31 PD patients and 25 controls. MiR-331-5p remained significantly increased in patients vs. controls. A bioinformatic analysis predicted that this miRNA could be involved in the regulation of genes related with PD and brain function (axon guidance, MPK signaling pathway or insulin signaling pathway). We concluded that miR-331-5p could be a candidate plasma miRNA to be studied in PD related pathwayseng
dc.description.sponsorshipAuthors thank the “Fundacion Parkinson Asturias” and “Obra Social Cajastur” for their support. This work was supported by grant 11/0093 from the Spanish “Fondo de Investigaciones Sanitarias-Fondos FEDER” European Union. LFC and LDM are predoctoral fellowships of FICYT-Principado de Asturiaseng
dc.language.isoengeng
dc.relation.isreferencedbyNo, esta versión no ha sido citadaeng
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/deed.eseng
dc.subjectMicroRNAseng
dc.subjectParkinson's diseaseeng
dc.subjectPlasma biomarkerseng
dc.subjectNeurodegenerationeng
dc.subjectmiR-331-5peng
dc.titleProfile of microRNAs in the plasma of Parkinson’s disease patients and healthy controlseng
dc.typepostprinteng
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