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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/7222


Título: Immunohistochemical localisation of rabbit haemorrhagic disease virus VP-60 antigen in early infection of young and adult rabbits
Autores: Prieto, J.M.
Fernández, F.
Alvarez, V.
Espí, A.
Martín, J. M.
Parra, F.
Palabras Claves: Conejos
Infección viral
Enfermedad hemorragica
Hepatocitos
Fecha Edición: 2000
Editor: Elsevier
Cita Bibliográfica: Prieto, J.M... [et al.]. Immunohistochemical localisation of rabbit haemorrhagic disease virus VP-60 antigen in early infection of young and adult rabbits. Research in Veterinary Science . 2000. ; 68(2) : 181-187
Resumen: This study evaluated the time course distribution of rabbit haemorrhagic disease virus (RHDV) structural protein VP60 in tissues from experimentally infected rabbits from three different age groups. Viral VP60 antigen could not be detected in tissue samples from animals under four weeks, and only a few hepatocytes (0·01 to 0·2 per cent) were stained in the 6-week-old animals. A 6- week-old rabbit euthanised at 72 hpi showed VP60-labelling in hepatocytes and macrophages close to areas of inflammation. Viral VP60 antigen was detected as early as 12 hpi in a few hepatocytes (0·03 per cent) from adult animals. Within this age group, the extent of hepatocyte labelling considerably increased at 18 (3·0 per cent), 24 (25·5 per cent), 36 (50 per cent) and 48 (60 per cent) hpi. Extrahepatic viral VP60 antigen was also detected at 36 and 48 hpi in spleen macrophages and lymphocytes from adult rabbits. These findings support the hypothesis that the hepatocyte is the only cell type in the liver able to support RHDV replication almost immediately after viral infection
URI: https://ria.asturias.es/RIA/handle/123456789/7222
ISSN: 0034-5288
Aparece en las Colecciones:Agroalimentación y Ganadería
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