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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/10948


Título: Drug-induced hyperploidy stimulates an antitumor NK cell response mediated by NKG2D and DNAM-1 receptors
Autores: Acebes-Huerta, Andrea
Lorenzo-Herrero, Seila
Folgueras, Alicia
Huergo-Zapico, Leticia
López-Larrea, Carlos
López-Soto, Alejandro
González, Segundo
Palabras Claves: ATM
Calreticulin
DNA damage
DNAM-1
ER stress
MICA
NKG2D
T cells
cancer immunosurveillance
hyperploidy
natural killer cells
Fecha Edición: 12-Ago-2015
Editor: OncoImmunology
Cita Bibliográfica: Andrea Acebes-Huerta, Seila Lorenzo-Herrero, Alicia R. Folgueras, Leticia Huergo-Zapico, Carlos Lopez-Larrea, Alejandro López-Soto & Segundo Gonzalez (2016) Drug-induced hyperploidy stimulates an antitumor NK cell response mediated by NKG2D and DNAM-1 receptors, OncoImmunology.2015;5(2):e1074378
Resumen: Formation of polyploid or aneuploid cells is a pathological hallmark of malignant tumors. Cell cycle checkpoint mechanisms play a crucial role in ensuring genomic integrity during mitosis, avoiding the generation of aneuploid cells. Additionally, cancer cell DNA ploidy is subjected to extrinsic controls operated by activation of adaptive immune responses mediated by T cells. NK cells exert a central role in the innate anticancer immunity; however, the mechanisms involved in the recognition of tumor cells by NK cells have not been fully elucidated. Herein, we report that drug-induced polyploidy in cancer cells activates antitumor responses mediated by NK cells. Thus, hyperploidy-inducing chemotherapeutic agents strongly upregulate the tumor expression of ligands for the NK cell activating receptors NKG2D and DNAM-1. Drug-induced hyperploidy modulated the repertoire of activating receptors and the cytokine profile of NK cells, rendering tumor cells more susceptible to NK cell-mediated lysis through the activation of NKG2D and DNAM-1 receptors. In addition, hyperploidization stimulated the production of IL-2 by CD4 T cells, which induced NK cell proliferation and activity. The stimulation of MICA, a key NKG2D ligand, in hyperploid cells was mainly mediated by ATM protein kinase. Likewise, pharmacological inhibition of key regulators of endoplasmic reticulum stress in certain cell models supports a role for this pathway in NKG2D ligand upregulation. Overall, our findings indicate that, besides the cytotoxic effect on tumor cells, the therapeutic activity of anti-mitotic drugs may be mediated by the induction of a coordinated antitumor immune response involving NK and T cells.
URI: https://ria.asturias.es/RIA/handle/123456789/10948
ISSN: 2162-402X
Aparece en las Colecciones:Sanidad

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