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| Campo Dublin Core | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Alvarez, Angel L. | - |
| dc.contributor.author | Barrio, Gloria del | - |
| dc.contributor.author | Kouri, Vivian | - |
| dc.contributor.author | Martínez, Pedro A. | - |
| dc.contributor.author | Suárez, Belén | - |
| dc.contributor.author | Parra, Francisco | - |
| dc.date.accessioned | 2019-03-01T08:44:47Z | - |
| dc.date.available | 2019-03-01T08:44:47Z | - |
| dc.date.issued | 2009 | - |
| dc.identifier.citation | Alvarez, A... [et al.]. In vitro anti-herpeticactivityofanaqueousextractfromtheplant Phyllanthus orbicularis. Phytomedicine . 2009 ; 16 : 960-966 | eng |
| dc.identifier.issn | 0944-7113 | - |
| dc.identifier.uri | https://ria.asturias.es/RIA/handle/123456789/11166 | - |
| dc.description.abstract | The Herpesviridae includes atleasteightviralspeciespathogenicforhumans,responsibleforawidevarietyof clinicalsymptoms.Thelackofaneffectivevaccineandthemoderatetohightoxicityoftheavailablesyntheticanti- herpescompoundsemphasisestheneedfornewinhibitors.Several Phyllanthus genus (Euphorbiaceae) membershave been widelyusedintraditionalmedicineandtheirbiologicalpropertieshavebeenintenselystudied.Inthisstudywe investigatedthe in vitro antiviral activityoftheCuban-endemicplant Phyllanthusorbicularis H.B.K. against Herpes simplexvirus type 1(HSV-1)and2(HSV-2)referencestrainsandclinicalisolateswithdifferentsensitivitiesto acyclovir.Theinhibitoryactivityon Humancytomegalovirus (HCMV)replicationwasalsoinvestigated.Theselectivity indexes (SI)foundfor Ph. orbicularis aqueousextractrangedfrom8.7to37.6.Studiesontheantiviralmechanisms involvedrevealedthatthedrugactedatearlystagesofherpesvirusreplication,possiblybyproducingavirucidaleffect,althoughfurtherinhibitionofintracellularreplicationeventscouldnotberuledout. | eng |
| dc.language.iso | eng | eng |
| dc.publisher | Science Direct/ Elsevier | eng |
| dc.relation.ispartof | Phytomedicine | eng |
| dc.relation.hasversion | 16 | eng |
| dc.relation.isreferencedby | Sí, esta versión ha sido citada | eng |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/deed.es | eng |
| dc.source | 960;966 | - |
| dc.subject | Phyllanthus | eng |
| dc.subject | HSV | eng |
| dc.subject | Citomegalovirus | eng |
| dc.subject | Etnomedicina | eng |
| dc.subject | Antiviral | eng |
| dc.subject.classification | Publicado | eng |
| dc.title | In vitro anti-herpeticactivityofanaqueousextractfromtheplant Phyllanthus orbicularis | eng |
| dc.type | article | eng |
| Aparece en las colecciones: | Agroalimentación y Ganadería Open Access DRIVERset | |
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