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https://ria.asturias.es/RIA/handle/123456789/11166| Título : | In vitro anti-herpeticactivityofanaqueousextractfromtheplant Phyllanthus orbicularis |
| Autor : | Alvarez, Angel L. Barrio, Gloria del Kouri, Vivian Martínez, Pedro A. Suárez, Belén Parra, Francisco |
| Palabras clave : | Phyllanthus HSV Citomegalovirus Etnomedicina Antiviral |
| Fecha de publicación : | 2009 |
| Editorial : | Science Direct/ Elsevier |
| Citación : | Alvarez, A... [et al.]. In vitro anti-herpeticactivityofanaqueousextractfromtheplant Phyllanthus orbicularis. Phytomedicine . 2009 ; 16 : 960-966 |
| Resumen : | The Herpesviridae includes atleasteightviralspeciespathogenicforhumans,responsibleforawidevarietyof clinicalsymptoms.Thelackofaneffectivevaccineandthemoderatetohightoxicityoftheavailablesyntheticanti- herpescompoundsemphasisestheneedfornewinhibitors.Several Phyllanthus genus (Euphorbiaceae) membershave been widelyusedintraditionalmedicineandtheirbiologicalpropertieshavebeenintenselystudied.Inthisstudywe investigatedthe in vitro antiviral activityoftheCuban-endemicplant Phyllanthusorbicularis H.B.K. against Herpes simplexvirus type 1(HSV-1)and2(HSV-2)referencestrainsandclinicalisolateswithdifferentsensitivitiesto acyclovir.Theinhibitoryactivityon Humancytomegalovirus (HCMV)replicationwasalsoinvestigated.Theselectivity indexes (SI)foundfor Ph. orbicularis aqueousextractrangedfrom8.7to37.6.Studiesontheantiviralmechanisms involvedrevealedthatthedrugactedatearlystagesofherpesvirusreplication,possiblybyproducingavirucidaleffect,althoughfurtherinhibitionofintracellularreplicationeventscouldnotberuledout. |
| URI : | https://ria.asturias.es/RIA/handle/123456789/11166 |
| ISSN : | 0944-7113 |
| Aparece en las colecciones: | Agroalimentación y Ganadería Open Access DRIVERset |
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