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Por favor, use este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/12545
Título : Effect of Type of Dialysis on CMV-Specific CD8+T Cells in Kidney Transplant Candidates
Autor : Vidal Castiñeira, José Ramón
Corte Iglesias, Viviana
Sobrino Díaz, Lucía
Pérez Fernández, Sonia
Melón, Santiago
López Larrea, Carlos
Díaz Corte, Carmen
Palabras clave : CMV
CMV-specific CD8+ T cells
peritoneal dialysis
Fecha de publicación : 19-jul-2019
Citación : Vidal-Castiñeira JR, Corte-Iglesias V, Sobrino-Diaz L, Pérez-Fernández S, Melón S, López-Larrea C, Díaz-Corte C. Effect of Type of Dialysis on CMV-Specific CD8+ T Cells in Kidney Transplant Candidates. Front Immunol. 2019 Jul 19;10:1680. doi: 10.3389/fimmu.2019.01680. eCollection 2019. PMID: 31379868
Resumen : Background: Dialysis is the first procedure to partially replace renal function in end-stage renal diseases, despite several adverse side effects, such as infections. The primary aim of this study was to evaluate the levels of immune CMV-specific CD8+ T cells in a representative cohort of pre-transplant patients receiving hemodialysis (HD) or peritoneal dialysis (PD). The secondary aim was to monitor the CMV-specific CD8+ T cells in kidney transplant recipients undergoing different types of dialysis during the first year following their transplant. Methods: Sixty-nine patients were enrolled and examined with respect to the type of dialysis they received. HLA class I dextramers for CMV were used to determine the quantity of CMV-specific CD8+ T cells. The CMV DNA viral load was also determined. Forty-two of the patients enrolled in the study underwent solid organ transplantation and were analyzed during their first year post-transplantation. Results: Patients receiving HD had fewer CMV-specific CD8+ T cells than those in PD (p < 0.05). We also observed that patients in PD had more CMV-specific CD8+ T cells during the follow-up period than those in HD (p < 0.05), independently of the CMV DNA. Finally, PD patients had a higher frequency of CD8+ Effector-Memory RA T cells (TEMRA) and a lower frequency of central memory T cells (TCM) than did HD patients. Conclusions: These results indicate the better status of CMV-specific T cell immunity in PD patients. The use of CMV T cell dextramers would be advantageous formonitoring the CD8+ T-specific response, enabling the use of prophylactic treatment to be optimized.
URI : https://ria.asturias.es/RIA/handle/123456789/12545
ISSN : 1664-3224
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