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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/12587


Título: Barley-ss-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition
Autores: María Vittoria, Arcidiacono
Carrillo López, Natalia
Panizo, Sara
Castro Grattoni, Anabel L
Valcheva, Petya
Ulloa, Catalina
Rodríguez Carrio, Javier
Cardús, Anna
Quirós Caso, Covadonga
Martínez Arias, Laura
Martínez Salgado, Carlos
Motilva, María José
Rodríguez Suárez, Carmen
Cannata Andía, Jorge B
Dusso, Adriana S
Palabras Claves: VASCULAR CALCIFICATION
OXIDATIVE STRESS
ANGIOTENSIN-II
BETA-GLUCAN
NEUTRAL SPHINGOMYELINASE
PARATHYROID HYPERPLASIA
TNF-ALPHA
EXPRESSION
DISEASE
CEREAL
Fecha Edición: 28-Nov-2019
Editor: NATURE PUBLISHING GROUP
Cita Bibliográfica: Arcidiacono MV, Carrillo-López N, Panizo S, Castro-Grattoni AL, Valcheva P, Ulloa C, Rodríguez-Carrio J, Cardús A, Quirós-Caso C, Martínez-Arias L, Martínez-Salgado C, Motilva MJ, Rodriguez-Suarez C, Cannata-Andía JB, Dusso AS. Barley-ss-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition. Sci Rep. 2019 Nov 28;9:17810. doi: 10.1038/s41598-019-54306-8. PMID: 31780737
Resumen: In chronic kidney disease (CKD), hyperphosphatemia-induced inflammation aggravates vascular calcification (VC) by increasing vascular smooth muscle cell (VSMC) osteogenic differentiation, ADAM17-induced renal and vascular injury, and TNFa-induction of neutral-sphingomyelinase2 (nSMase2) to release pro-calcifying exosomes. This study examined anti-inflammatory beta-glucans efficacy at attenuating systemic inflammation in health, and renal and vascular injury favoring VC in hyperphosphatemic CKD. In healthy adults, dietary barley beta-glucans (B beta glucans) reduced leukocyte superoxide production, inflammatory ADAM17, TNF alpha, nSMase2, and pro-aging/pro-inflammatory STING (Stimulator of interferon genes) gene expression without decreasing circulating inflammatory cytokines, except for gamma-interferon. In hyperphosphatemic rat CKD, dietary Bssglucans reduced renal and aortic ADAM17-driven inflammation attenuating CKD-progression (higher GFR and lower serum creatinine, proteinuria, kidney inflammatory infiltration and nSMase2), and TNF alpha-driven increases in aortic nSMase2 and calcium deposition without improving mineral homeostasis. In VSMC, B beta glucans prevented LPS- or uremic serum-induced rapid increases in ADAM17, TNF alpha and nSMase2, and reduced the 13-fold higher calcium deposition induced by prolonged calcifying conditions by inhibiting osteogenic differentiation and increases in nSMase2 through Dectin1-independent actions involving B beta glucans internalization. Thus, dietary B beta glucans inhibit leukocyte superoxide production and leukocyte, renal and aortic ADAM17- and nSMase2 gene expression attenuating systemic inflammation in health, and renal injury and aortic calcification despite hyperphosphatemia in CKD.
URI: https://ria.asturias.es/RIA/handle/123456789/12587
ISSN: 2045-2322
Aparece en las Colecciones:Sanidad

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