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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/1290


Título: Eligibility for and outcome of treatment of latent tuberculosis infection in a cohort of HIV-infected people in Spain
Autores: Díez, Mercedes
Bleda, María J.
Aldamiz, Mikel
Camafort, Miguel
Camino, Xabier
Cepeda, Concepción
Costa, Asunción
Ferrero, Oscar
Geijo, Paloma
Iribarren, Jose Antonio
Moreno, Santiago
Moreno, María E.
Labarga, Pablo
Pinilla, Javier
Portu, Joseba
Pulido, Federico
Rosa, Carmen
Santamaría, Juan M.
Telenti, Mauricio
Trapiella, Luis
Trastoy, Monica
Viciana, Pompeyo
Fecha Edición: 2010
Editor: BioMed Central
Cita Bibliográfica: BMC Infectious Diseases.2010;10:267
Resumen: Background: Previous studies have demonstrated the efficacy of treatment for latent tuberculosis infection (TLTBI) in persons infected with the human immunodeficiency virus, but few studies have investigated the operational aspects of implementing TLTBI in the co-infected population.The study objectives were to describe eligibility for TLTBI as well as treatment prescription, initiation and completion in an HIV-infected Spanish cohort and to investigate factors associated with treatment completion. Methods: Subjects were prospectively identified between 2000 and 2003 at ten HIV hospital-based clinics in Spain. Data were obtained from clinical records. Associations were measured using the odds ratio (OR) and its 95% confidence interval (95% CI). Results: A total of 1242 subjects were recruited and 846 (68.1%) were evaluated for TLTBI. Of these, 181 (21.4%) were eligible for TLTBI either because they were tuberculin skin test (TST) positive (121) or because their TST was negative/unknown but they were known contacts of a TB case or had impaired immunity (60). Of the patients eligible for TLTBI, 122 (67.4%) initiated TLTBI: 99 (81.1%) were treated with isoniazid for 6, 9 or 12 months; and 23 (18.9%) with short-course regimens including rifampin plus isoniazid and/or pyrazinamide. In total, 70 patients (57.4%) completed treatment, 39 (32.0%) defaulted, 7 (5.7%) interrupted treatment due to adverse effects, 2 developed TB, 2 died, and 2 moved away. Treatment completion was associated with having acquired HIV infection through heterosexual sex as compared to intravenous drug use (OR:4.6; 95% CI:1.4-14.7) and with having taken rifampin and pyrazinamide for 2 months as compared to isoniazid for 9 months (OR:8.3; 95% CI:2.7-24.9). Conclusions: A minority of HIV-infected patients eligible for TLTBI actually starts and completes a course of treatment. Obstacles to successful implementation of this intervention need to be addressed.
URI: https://ria.asturias.es/RIA/handle/123456789/1290
ISSN: 1471-2334
Aparece en las Colecciones:Sanidad
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