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Título : The secretome atlas of two mouse models of progeria
Autor : Quintana-Torres, Diego
Valle-Cao, Alejandra
Bousquets-Muñoz, Pablo
Freitas-Rodríguez, Sandra
Rodríguez, Francisco
Lucía, Alejandro
López-Otín, Carlos
López-Soto, Alejandro
Rodríguez Folgueras, Alicia
Palabras clave : Bioquímica
Envejecimiento
Progeria
Proteómica
Fecha de publicación : 16-oct-2023
Editorial : Wiley
Citación : Aging Cell (2023); doi:10.1111/acel.13952
Citación : ;22
Resumen : Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease caused by nuclear envelope alterations that lead to accelerated aging and premature death. Several studies have linked health and longevity to cell-extrinsic mechanisms, highlighting the relevance of circulating factors in the aging process as well as in age-related diseases. We performed a global plasma proteomic analysis in two preclinical progeroid models (LmnaG609G/G609G and Zmpste24−/− mice) using aptamer-based proteomic technology. Pathways related to the extracellular matrix, growth factor response and calcium ion binding were among the most enriched in the proteomic signature of progeroid samples compared to controls. Despite the global downregulation trend found in the plasma proteome of progeroid mice, several proteins associated with cardiovascular disease, the main cause of death in HGPS, were upregulated. We also developed a chronological age predictor using plasma proteome data from a cohort of healthy mice (aged 1–30 months), that reported an age acceleration when applied to progeroid mice, indicating that these mice exhibit an “old” plasma proteomic signature. Furthermore, when compared to naturally-aged mice, a great proportion of differentially expressed circulating proteins in progeroid mice were specific to premature aging, highlighting secretome-associated differences between physiological and accelerated aging. This is the first large-scale profiling of the plasma proteome in progeroid mice, which provides an extensive list of candidate circulating plasma proteins as potential biomarkers and/or therapeutic targets for further exploration and hypothesis generation in the context of both physiological and premature aging.
URI : https://ria.asturias.es/RIA/handle/123456789/14726
ISSN : 1474-9718
Aparece en las colecciones: Bioquímica

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