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Título : Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus
Autor : Coto, Eliecer
Torres, Armando
Díaz-Corte, Carmen
Díaz-Molina, Beatriz
Ortega, Francisco
Arias, Manuel
Díaz, Juan M.
Selgas, Rafael
López-Larrea, Carlos
Ruiz-Ortega, Marta
Ortiz, Alberto
González, Elena
Campistol, J. M.
Álvarez, Victoria
Palabras clave : Postransplant diabetes
KCNJ11
Genetic association
Fecha de publicación : 2012
Resumen : KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association
URI : https://ria.asturias.es/RIA/handle/123456789/1621
Aparece en las colecciones: Open Access DRIVERset
Sanidad

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