Datos del Documento

Por favor, use este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/2662
Título : Bone and Vascular Health and the Kidney
Autor : Román-García, Pablo
Cabezas-Rodríguez, Iván
Rodríguez-García, Minerva
Palabras clave : Bone
Vascular calcification
Bone density
Bone fractures
Low Bone Mass
Bone disease
Fecha de publicación : 2012
Resumen : In patients with progressive chronic kidney disease (CKD), the homeostatic mechanisms regulating calcium and phosphate metabolism suffer important changes resulting in low serum levels of calcitriol and calcium and phosphorous retention. The regulatory mechanisms fail and several chronic kidney disease mineral bone disorders (CKD-MBD) occur, including bone disease, vascular calcifications, cardiovascular disorders, bone fragility fractures and reduced survival. Vascular calcification, bone loss and increased fracture risk are severe disorders associated with ageing in chronic CKD, but also generally speaking. Several epidemiological studies have shown the relationship between impaired bone metabolism, vascular calcification and increased mortality. Recent data suggest this association may be not just a consequence of ageing; the common occurrence of severe cases of vascular calcifications together with low bone activity and osteoporosis suggests there might be some direct biological links between the bone and the vascular systems. New challenging experimental data suggest that once the severe vascular calcification appears, vessels may develop a mechanism to diminish the vascular mineralization in the artery wall, this defensive mechanism may have a negative impact favouring the reduction of bone mass.
URI : https://ria.asturias.es/RIA/handle/123456789/2662
Aparece en las colecciones: Open Access DRIVERset

Archivos en este documento:
Fichero Tamaño Formato  
Archivo.pdf195.41 kBAdobe PDFVer/Abrir
Mostrar el registro Completo

Ver estadísticas del documento

Este documento está sujeto a una licencia Creative Commons: Licencia Creative Commons Creative Commons