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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/2742


Título: Association between a MYH9 polymorphism (rs3752462) and renal function in the Spanish RENASTUR cohort.
Autores: Coto, Eliecer
Gómez, Juan
Tranche, Salvador
Miguélez, Kevin
Ortega, Francisco
Díez, Beatriz
Sánchez, Emilio
Marín, Rafael
Arenas, Jorge
Álvarez, Victoria
Palabras Claves: MYH9 polymorphisms
Glomerular filtration
Renal function
Fecha Edición: 2013
Resumen: The MYH9 gene encodes a protein that is expressed in the kidney glomerular podocytes. MYH9 single nucleotide polymorphisms (SNPs) have been linked to the risk for chronic kidney disease (CKD) and end stage renal disease. Our aim was to determine whether MYH9 SNPs were associated with renal disease in Spanish Caucasians. The RENASTUR cohort consisted of 592 Spanish Caucasians, aged 55-85 years. They were genotyped for SNPs rs3752462 and rs4821480, that tagged haplotype E. The main values between individuals with a glomerular filtration rate (eGFR) <60 and ≥60 ml/ min./1.73 m2 were statistically compared. The next variables were significantly associated with the eGFR in the univariate analysis: age, gender, type 2 diabetes, total cholesterol, total LDL-cholesterol, and the MYH9 rs3752462 (TC+TT genotypes; p=0.003). This SNP remained significantly associated with the eGFR in the multivariate analysis. In conclusion, SNP rs3752462 was an independent predictor of reduced eGFR in the Spanish RENASTUR population. The genotyping of this MYH9 SNP could help to identify individuals at risk of developing CKD.
URI: https://ria.asturias.es/RIA/handle/123456789/2742
Aparece en las Colecciones:Sanidad
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