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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/2761


Título: Defective Adaption of Erythrocytes During Acute Hypoxia Injury in an Elderly Population
Autores: Neitzert, Kim
Fernández, María
Vega-Naredo, I.
Caballero, Beatriz
García-Macia, Marina
Suárez, Francisco M.
Rodríguez-Colunga, María J.
Solano, Juan José
Coto Montes, Ana
Palabras Claves: Aging
Low oxygen saturation
Oxidative stress
RBC
Fecha Edición: 2011
Editor: The Gerontological Society of America.
Cita Bibliográfica: J Gerontol A Biol Sci Med Sci. 2011;66(4):376-84
Resumen: The present study investigated the changes in several erythrocyte oxidative stress biomarkers in hypoxic elderly individuals to analyze the deleterious effects of low oxyhemoglobin saturation in an elderly population. We collected blood samples from one normoxic middle-aged group and two groups composed of individuals older than 75 years of age: one normoxic group and one hypoxic group. Aging appeared to provoke a defective erythrocyte antioxidant defense associated with increased oxidative damage in the elderly population. Acute hypoxia activated an insufficient antioxidant defense response as suggested by the oxidative damage observed. The oxidative imbalance presented in older participants and increased in hypoxia participants had a direct effect on glyceraldehyde-3-phosphate dehydrogenase cell distribution. Oxidative stress levels altered Band 3 protein and mediated caspase-3 activation in erythrocyte from the aged group although it was not extended to hypoxic individuals. Therefore, aged participants appeared to activate an insufficient antioxidant response against hypoxia-related oxidative stress.
URI: https://ria.asturias.es/RIA/handle/123456789/2761
ISSN: 1079-5006
Aparece en las Colecciones:Sanidad
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