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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/441


Título: Matrix metalloproteinase 1 promoter polymorphisms and risk of myocardial infarction: a case-control study in a Spanish population
Autores: Coto García, Eliecer
Reguero, Julián R.
Cannata Andía, Jorge B.
Lozano, Iñigo
Avanzas, Pablo
Morís, César
Rodríguez, Isabel
Palabras Claves: Myocardial infarction
Matrix metalloproteinase 1
Polymorphisms
Fecha Edición: 2009
Editor: Lippincott Williams & Wilkins
Cita Bibliográfica: Coronary Artery Dis
Resumen: Inherited and acquired risk factors contribute to the development of the atherosclerotic lesion and its most common clinical manifestation, myocardial infarction (MI). Multiple studies have suggested a role for matrix metalloproteinase (MMPs) in atherosclerosis, and several functional polymorphisms in the MMP-1 gene have been linked to the risk of MI. The aim of this study was to evaluate the association between MMP-1 promoter polymorphisms and early MI in a Spanish cohort. Methods: We performed a case-control study with 261 unrelated patients who had suffered an MI before 55 years and 194 healthy controls, all male and smokers. The genotypes for the three MMP-1 promoter polymorphisms -1607 1G/2G, -519 A/G, and -340 T/C were determined through PCR-RFLP. Allelic, genotypic, and haplotypic frequencies were statistically compared between groups. Results: Frequencies of the three polymorphisms did not differ between patients and controls. The -1607 1G/2G and -519 A/G variants were in linkage disequilibrium. Analysis of the haplotype frequencies showed significant associations of the 2G-1607-G-519-T-340 (p<0.006; OR=2.40; 95% CI=1.27-4.55) and 1G-1607-G-519-T-340 (p<0.05, OR=0.68; 95% CI=0.50-0.94) haplotypes with the risk of early MI. Conclusion: MMP-1 promoter polymorphisms are associated with the risk of early MI in a Spanish population of smoking males
URI: https://ria.asturias.es/RIA/handle/123456789/441
ISSN: 1473-5830
Aparece en las Colecciones:Sanidad
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