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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/676


Título: Parathyroid gland regulation: contribution of the IN VIVO and IN VITRO screening models.
Autores: Román-García, Pablo
Fernández Martín, José L.
Cannata Andía, Jorge B.
Palabras Claves: In vivo models
In vitro models
Parathyroid hormone
Calcium
Phosphorous
FGF-23
Parathyroid function
Secondary hyperparathyroidism
Fecha Edición: 2010
Editor: Informa Healthcare
Cita Bibliográfica: Expert opin drug discov.2010
Resumen: Importance of the field: The current regulation of parathyroid hormone and the development of parathyroid disorders in chronic kidney disease involve complex mechanisms. Factors such as calcium, phosphorous, calcitriol, vitamin D receptor, calcium-sensing receptor and fibroblast growth factor 23 (FGF23), play a key role in the regulatory process in the pathogenesis of secondary hyperparathyroidism. Areas covered in this review: This review provides an analysis of published results related to the different models and approaches used to study the mechanisms involved in the pathogenesis of secondary hyperparathyroidism. The review includes clinical studies, animal and ex vivo/in vitro models which have been extensively used in this area. What the reader will gain: Readers will have an overview of the main findings and progresses achieved in the knowledge of the parathyroid function combining the results obtained from the different models used to understand the parathyroid gland regulation. Take-home message: Each of the available models used to study the complex system of parathyroid regulation has advantages and limitations; therefore, it is necessary to combine the information obtained from more than one model in order to have a more complete knowledge of the mechanisms involved in parathyroid hormone regulation.
URI: https://ria.asturias.es/RIA/handle/123456789/676
ISSN: 1746-045X
Aparece en las Colecciones:Sanidad
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