Zinc-Catalyzed Functionalization of Si-H Bonds with 2-furyl carbenoids through three-component coupling

Abstract

A three-component coupling of alk-2-ynals, 1,3-dicarbonyls and silanes is reported. ZnCl2 serves as an inexpensive and low-toxic catalyst for the overall transformation, which involves Knoevenagel condensation, cyclization, and carbene Si[BOND]H bond insertion. The process takes place with high atom economy in the absence of organic solvents and shows a broad scope. This reaction is also applicable to the functionalization of oligomeric siloxanes.