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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/683


Título: Concentraciones séricas preoperatorias de antígeno carbohidrato 15.3
Autores: Garrido Pumar, M.
Arias, José I.
Palabras Claves: CA15.3
Breast cancer
Tissue clinical-biological parameters
Fecha Edición: 2006
Editor: Sociedad Española de Medicina Nuclear
Cita Bibliográfica: Rev Esp Med Nucl. 2006;25(3):180-3
Resumen: Summary.—Objective. To study the possible associations between preoperative serum CEA and CA15.3 levels and different clinical-biological parameters of infiltrating ductal carcinomas of the breast (IDC). Patients and method. Preoperative serum CA15.3 and CEA levels were determined in 255 and 224 females, respectively, having IDC. We assayed the cytos lic levels of estrogen receptor, pS2, cathepsin D and hyaluronic acid, as well as the levels of epidermal growth factor receptor in cell surfaces. Tumor size, axillary involvement (N), distant metastasis (M), histological grade (HG) and cellular S-phase (SP) were taken into account. Results. 22 IDC were positive for CA15.3 (> 40 U/ml) and they had greater global tumor size (p < 0.001), > 2 cm (p:0.005) and distant metastasis (p < 0.001). 19 IDC were positive for CEA (> 4 ng/ml) and they had greater global tumor size (p < 0.001), > 2 cm (p < 0.001), > 5 cm (p: 0.052) and global S-phase values (p: 0.062), and were more frequently N + (p:0.045), > 3N + (p: 0.001) and > 10 N + (p < 0.001), M + (p: 0.004), HG3 (p: 0.091) and SP > 7% (p: 0.006) Conclusions. Our results led us to the following: In patients having IDC of the breast, preoperative serum CA15.3 levels are associated with greater tumor size and distant metastasis, while pre-treatment CEA serum levels are associated moreover with axillary involvement; we have not observed any correlation between serum levels of both antigens and the hormonal status of the tumor; these results had physiopathological interest but reduced clinical value in pretreatment breast carcinomas due to their low sensitivity of both markers. However, they are useful in the follow-up of the patients when assesing serum concentrations of both markers, since they contribute to knowing the patients’clinical satus better.
URI: https://ria.asturias.es/RIA/handle/123456789/683
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