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Utilice este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/705


Título: Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H
Autores: Álvarez, Victoria
Martín, María
Díaz, Marta
Corao, Ana I.
Alonso, Belén
Díaz Molina, Beatriz
Lozano, Iñigo
Avanzas, Pablo
Morís, César
Reguero, Julián R.
Rodríguez, Isabel
López Larrea, Carlos
Cannata Andía, Jorge B.
Batalla, Alberto
Ruiz-Ortega, Marta
Martínez Camblor, Pablo
Coto García, Eliecer
Palabras Claves: Atherosclerosis
Myocardial infarction
Mitochondria
Mitochondrial transcription factor
Haplogroups
Fecha Edición: 2010
Resumen: The main objective of this research was to define the association between common mitochondrial DNA (mtDNA) polymorphisms and mitochondrial transcription A gene (TFAM) variants and myocardial infarction (MI) in patients with atherosclerotic diseased vessels. Ten mitochondrial polymorphisms that defined the nine common European haplogroups were genotyped in 500 male patients with early onset MI (<55 years) and at least one atherosclerotic coronary vessel (angiographically confirmed), and 500 healthy controls. In addition, we searched for DNA variants in the coding region of the TFAM gene and compared patients and controls for the allele and genotype frequencies. Early onset MI was strongly associated with male gender and tobacco smoking in our population. MtDNA haplogroup H (defined by allele 7028 C) was significantly more frequent in a first group of patients (n=250) compared to controls (n=300), and the association was confirmed in a second group of only smokers (250 patients and 200 controls). For total patients and controls, we obtained a p=0.002 (OR=1.50; 95% CI= 1.17-1.92) for H vs. the other haplogroups. We found four common TFAM polymorphisms, with allele/genotype frequencies that did not differ between patients and controls. In conclusion, mitochondrial haplogroup H was associated with early onset MI in male smokers. Our work supported a role for the mtDNA variation in the risk for atherosclerosis and ischemic associated events, likely due to differences in mitochondrial function and reactive oxygen production between the different haplogroups.
URI: https://ria.asturias.es/RIA/handle/123456789/705
Aparece en las Colecciones:Sanidad
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