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Por favor, use este identificador para citar o enlazar este documento: https://ria.asturias.es/RIA/handle/123456789/7646
Título : Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched b-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination
Autor : Cuetos, Aníbal
García-Ramos, Marina
Fischereder, Eva-Maria
Díaz-Rodríguez, Alba
Grogan, Gideon
Gotor, Vicente
Kroutil, Wolfgang
Lavandera, Iván
Palabras clave : Biocatálisis
Transaminasas
Fecha de publicación : 2-feb-2016
Editorial : Wiley-VCHWiley-VCH Verlag GmbH & Co
Citación : A. Cuetos, M. Garcia-Ramos, E.-M. Fischereder, A. Diaz-Rodriguez, G. Grogan, V.Gotor. W. Kroutil and I. Lavandera, Catalytic promiscuity of transaminases: Preparation of enantioenriched β- fluoroamines via formal tandem hydrodefluorination-deamination. Angew. Chem. Int. Ed. 2016, 55, 3144-3147.
Resumen : Transaminases are valuable enzymes for industrial biocatalysis and enable the preparation of optically pure amines. For these transformations they require either an amine donor (amination of ketones) or an amine acceptor (deamination of racemic amines). Herein transaminases are shown to react with aromatic b-fluoroamines, thus leading to simultaneous enantioselective dehalogenation and deamination to form the corresponding acetophenone derivatives in the absence of an amine acceptor. A series of racemic b-fluoroamines was resolved in a kinetic resolution by tandem hydrodefluorination/deamination, thus giving the corresponding amines with up to greater than 99% ee. This protocol is the first example of exploiting the catalytic promiscuity of transaminases as a tool for novel transformations.
URI : https://ria.asturias.es/RIA/handle/123456789/7646
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