Datos del Documento
|Título :||Prognostic Influence of Tumor Stroma on Breast Cancer Subtypes|
|Autor :||Cid, Sandra|
Fernández-Muñiz, Pablo Igancio
González, Luis O.
Vizoso, Francisco J.
|Palabras clave :||Cancer-associated fibroblasts|
Intratumoral inflammatory cells
|Fecha de publicación :||feb-2018|
|Citación :||Cid, Sandra; Eiro, Noemí; Fernández, Berta; Sánchez, Rosario; Andicoechea, Alejandro; Fernández-Muñiz, Pablo Ignacio; González, Luis O; Vizoso, Francisco J. Prognostic Influence of Tumor Stroma on Breast Cancer Subtypes. Clin Breast Cancer. 2018 Feb;18(1):e123-e133|
|Resumen :||Aims: The objective of the present work was to evaluate the impact of the phenotype of both intratumoral mononuclear inflammatory cells (MICs) and cancer-associated fibroblast (CAFs), assessed as to their expression of MMPs and TIMPs on prognosis in different breast cancer subtypes. Materials and Methods: 247 tumors of patients with primary ductal invasive breast cancer were categorized into one of four major subtypes, using the three standard immunohistochemical markers (ER, PR and HER/Neu 2 receptor status). An immunohistochemical study was performed using tissue arrays and specific antibodies against matrix metalloproteinase (MMP)-9, -11 and -14, and tissue inhibitors of metalloproteinase (TIMP)-1 and –2. Results: MMP-11 expression by MICs was significantly and strongly associated with prognosis in all breast cancer subtypes. There were other significant associations with poor prognosis in Luminal A tumors: expressions of MMP-9, -11, and TIMP-2 by CAFs, in Luminal B tumors: MMP-14 expression by MICs and TIMP-2 expression by MICs, in HER-2-positive tumors: expression of MMP-9 by MICs and in triple-negative breast cancers (TNBC): expression of TIMP-1 by MICs. Conclusion: Characterization of both tumor stromal CAFs and MICs, with regard to the expression of MMPs and TIMPs, improve the prognostic evaluation of all breast cancer subtypes.|
|Aparece en las colecciones:||Open Access DRIVERset|
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