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Título : Isolation and characterization of <i>nudCi> from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF-AH(I) activity
Autor : Riera, José
Rodríguez, René
Teresa Carcedo, María
M. Campa, Víctor
Ramos, Sofía
Palabras clave : Monocytes/macrophages
Inflammation
Platelet activating factor acetylhydrolase
nudC
Fecha de publicación : 26-jun-2007
Editorial : Elsevier B.V. on behalf of the Federation of European Biochemical Societies
Citación : - Riera, J; Rodriguez, R; Carcedo, MT; Campa, VM; Ramos, S; Lazo, PS. Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PXF-AH(I) activity. FEBS Lett. 2007. 581. (16). p. 3057-3062. DOI: 10.1016/j.febslet.2007.05-065.
Resumen : We report the characterization of a cDNA induced in mouse macrophages that encodes a 332-amino acid protein with extensive sequence identity with members of the mammalian nudC-like genes. The interaction between mNUDC and the regulatory b subunit of platelet activating factor acetylhydrolase I (PAF-AH(I)) shown in this article indicates a new function of NUDC. Thus, we show that NUDC increases the catalytic activity of PAF-AH(I) and that this regulatory activity is located in the carboxyl terminal half of the protein which is highly conserved. This suggests a novel function for mammalian nudC-like genes as anti-inflammatory proteins.
URI : https://ria.asturias.es/RIA/handle/123456789/14914
ISSN : 1873-3468
Aparece en las colecciones: Sanidad

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